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HAYWARD, Calif., Feb. 10 /PRNewswire/ Arete Therapeutics Inc. today announced the initiation of a Phase IIa clinical trial for AR9281, an orally administered Lacoste Jacket Kids
drug target that differentiates it from currently marketed diabetes medications. With this promising drug profile, AR9281 has the potential to provide safe and effective therapy for patients with type 2 diabetes either as monotherapy or in combination with existing treatment regimens."
Arete Therapeutics Initiates Phase IIa Clinical Trial for AR9281 a Novel s EH Inhibitor to Treat Type 2 Diabetes Phase II Study in Patients with
Arete Therapeutics Inc.
Arete Therapeutics is a privately held biotechnology company dedicated to the discovery and development of novel drugs to treat type 2 diabetes, hypertension and inflammatory disorders. It is the world's leading company focused on s EH, an important enzyme for the metabolism of arachidonic acid that plays an essential role in metabolic, inflammatory and cardiovascular physiology. The Company was founded by Dr. Bruce Hammock, a Professor at the University of California, Davis, who discovered s EH. The Company has raised a total of over $51 million in Series A financing led by Frazier Healthcare Ventures, Alta Partners, Three Arch Partners, Burrill Company and Altitude Life Science Ventures. (ASTM) Heart Trial on Hold After One Adverse Event
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"Our AR9281 Phase II clinical trial program breaks new ground in two key areas. "AR9281 has demonstrated an excellent safety profile and activity in multiple animal models of type 2 diabetes, and has the advantage of inhibiting a novel Lacoste Belt For Men
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The Phase IIa multicenter, double blind, placebo controlled study will enroll 150 pre diabetic patients with impaired glucose tolerance, mild obesity and mild to moderate hypertension. All patients enrolled in the study will be treatment nave for type 2 diabetes medications. The trial will evaluate two schedules of AR9281 and placebo using a parallel design to determine the feasibility of twice a day dosing. Each patient will receive 28 days of treatment. Endpoints for the trial include safety, tolerability, reduction of blood pressure and various measures of glucose and lipid metabolism, with results expected in the first quarter of 2010.
soluble epoxide hydrolase (s EH) inhibitor being developed for the treatment of type 2 diabetes. S EH is an enzyme involved in the metabolism of arachidonic acid, a key signaling molecule implicated in diabetes, hypertension and inflammatory disorders.
The results of a Phase I clinical program consisting of two double blind, placebo controlled studies demonstrated that AR9281 was safe and well tolerated in healthy volunteers. The studies met all safety, tolerability, pharmacokinetic and pharmacodynamic endpoints. In addition, AR9281 Polo Shirts Girl has shown favorable results in various published and proprietary in vitro and in vivo assays for potency, selectivity, efficacy, ADME, toxicity and safety.
"AR9281 operates within the third branch of the arachidonic acid pathway and represents a potentially more specific and selective approach to intervene in metabolic and inflammatory diseases. The first two branches of this critical regulatory pathway have been targeted by several commercially successful marketed anti inflammatory drugs including Aspirin(R) (acetylsalicylic acid), Motrin(R) (ibuprofen), Singulair(R) (Montelukast) and Celebrex(R) (celecoxib).
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